Skip to main content

Prediction of mortality from mesothelioma

Two series of results, which are less discussed in public, are certainly more important.

The first concerns the estimated lifetime probabilities of dying from mesothelioma in recent generations, compared with the older ones. For instance, we found that, in France, these lifetime probabilities were increasing in the new generations (we estimated a lifetime risk of 0.8% for men born in 1965–68), while these lifetime probabilities were found to be decreasing in UK and US studies. This might be explained by the different patterns of asbestos consumption in these three countries.

The second concerns the analysis of mortality in women. We did not find any trend in the mortality in females, which is in line with the results of Price in USA (Peto did not study women’s mortality). This is certainly reassuring, as the opposite would be expected if environmental exposures to asbestos played a significant part in the mortality from mesothelioma.

Labels:

Comments

Post a Comment

Popular posts from this blog

The mesothelial cell

The mesothelial cells line the serosal cavities of the body, the pleural, peritoneal and pericardial spaces. Geographically, across the serosal surfaces, mesothelial cells canbe seen to have a variety of morphologies between flat or cuboidal and showing few or a dense forest of microvilli. Although their important in vivo functions have not been identified, they have the potential to regulate cell traffic, the balance between coagulation and fibrinolysis, cell proliferation, and fibrogenesis within and around the pleural space. They likely represent the progenitor cell for mesothelioma. In in vitro studies, the mesothelial cell demonstrates a multitude of abilities. Mesothelial cells can produce most of the components of the submesothelial matrix, at amounts comparable to that of fibroblasts. They can also release growth factors such as TGF-beta and insulin-like growth factorI. The cells may regulate the fibrinolytic and procoagulant activities on their cell surface and in the pleural ...
Post a Comment
Read more

Novel Molecular, Epidemiological, and Therapeutic Issues in Mesothelioma: The Role of SV40

The rise in mesothelioma cases that has occurred since 1950 has been associated with the widespread commercial use of asbestos. However, less than 10% of asbestos workers exposed to high levels of asbestos actually develop the disease, suggesting that additional factors may increase an individual’s susceptibility to the carcinogenic effects of asbestos. In addition, about 20% of mesotheliomas are not associated with asbestos exposure, suggesting that alternative factors may also cause mesothelioma. * The SV40 SV40 is a DNA tumour virus which was introduced into a significant portion of the human population between 1955 and 1963 through polio vaccines and adenovaccines contaminated with the virus. SV40 and human tumours The discovery that SV40 produced tumours in hamsters led to the PCR analysis of human mesotheliomas for the presence of SV40. Our group was the first to investigate whether there was any correlation between Polyomavirus and mesothelioma, and this was accom- plished in tw...
Post a Comment
Read more

Mesothelioma Article: FREE DOWNLOAD

M alignant mesothelioma is a 20th century phenomenon and as we begin a new century it is timely to review the clinical, research, epidemiological and legal aspects of this disease. I t is a canser, and canser is " a slang or slang-like term for any malignant growth or tumor caused by abnormal and uncontrolled cell division". Cancer affects people at all ages with the risk for most types increasing with age. Cancer caused about 13% of all human deaths in 2007 (7.6 million). T umor is derived, via the Old French tumour , from the Latin tumor "swelling". It originally meant an abnormal swelling of the flesh. In contemporary English, tumor is synonymous with solid neoplasm. A tumor may be benign, pre-malignant or malignant. The nature of the tumor is determined by a pathologist after examination of the tumor tissues from a biopsy or a surgical excision specimen. T he epidemic of mesothelioma has been seen throughout the world, not just in Australia. In Europe mesot...
Post a Comment
Read more